Transplantation for Lymphoma: Good for the Brain as Well as the Body?
Posted on 11/29/2011
Primary central nervous system (CNS) non-Hodgkin lymphoma can involve the brain, spinal cord, meninges, cranial nerves, and eyes. Data from the Central Brain Tumor Registry of the United States indicate that approximately 2.4% of primary brain tumors are lymphomas.
Primary diffuse large B cell lymphoma of the CNS is recognized as a distinct entity in the latest World Health Organization Classification of lymphoid tumors, although other histologic subtypes of primary and secondary CNS lymphoma may be seen. According to the SEER database, the median survival of patients with primary CNS lymphoma has doubled over the last 30 years, although the 5-year survival is only approximately 25%. The prognosis for those who relapse is poor.
Philip J. Bierman, James O. Armitage
Biol Blood Marrow Transplant-:1-2, 2011
